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Kuwano T, Nakao S, Yamamoto H, Tsuneyoshi M, Yamamoto T, Kuwano M, et al

Hematoxylin and eosin (H&E) and Safranin O staining demonstrated extensive destruction of trabecular architecture and marrow necrosis in femoral head tissues from GC-induced ONFH patients, markedly exceeding the pathological changes observed in non-ONFH controls (Fig

However, this process still faces several technical bottlenecks, mechanistic controversies, and challenges related to therapeutic adaptability

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All examined the effect of combined folate and vitamin B12 supplementation (most with vitamin B6 or pyridoxine as well) on the rate of thrombotic vascular events in high-risk subjects

This is supported by recent research, which shows that supplementation of folic acid and vitamins B6 and B12 may reduce the risk of AMD