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The IVD is a highly rhythmic tissue that undergoes daily changes in loading patterns, influenced by the cycles of activity and rest

10.1074/mcp.T600050-MCP200 76 ShinN.-Y.LiuQ.StamerS

The cell viability was assessed by Hoechst staining of the nucleus (see Methods) and hence assessment of total cell numbers after 72 h of treatment, which is a good proxy for cell survival and cell growth upon prolonged compound exposure

673 Prolonged PERK activation suppresses global protein synthesis, leading to synaptic failure and neuronal death 674 These disruptions are central to the pathology of neurodegeneration, as demonstrated in animal models

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reported 2 cases of GBS with antecedent Chikungunya infection
