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Summary Vitamin B12 injections are very safe

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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

The energy boost from B12 is often the first noticeable change, with many patients reporting improved alertness and reduced fatigue within the first few days after their initial injection

Not only is it a naturally occurring peptide with an established safety profile, but it's also available in meaningful concentrations that may help with age management

In the group with a history of gastrectomy, 1 patient was taking hypnotics and anti-parkinsonism drugs, 1 patient had a history of chemotherapy, and 1 patient was taking hypnotics and had a history of chemotherapy