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Additionally, high specificity and selectivity for CBS inhibition, without off-target effects, must be ensured for therapeutic use

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EMBO J 23:48024812 de Keizer PL, Packer LM, Szypowska AA, Riedl-Polderman PE, van den Broek NJ, de Bruin A, Dansen TB, Marais R, Brenkman AB, Burgering BM (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence

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Research models demonstrated increased wheel-running activity, indicating that senescent cell elimination can restore physical abilities and vitality