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In methaemoglobinamia (A), the active drug metabolite oxidises haemoglobin (Hb) to methaemoglobin (MetHb)

Watch for: Energy crashes: Needing afternoon naps, struggling to finish workouts, losing the drive to pursue hobbies Body composition changes: Losing muscle despite exercise, accumulating belly fat despite decent diet Sexual changes: Reduced spontaneous desire, erectile difficulties, decreased satisfaction Mood shifts: Increased irritability, mild depression, loss of competitive drive Cognitive changes: Trouble with word recall, decreased mental sharpness, reduced problem-solving ability A classic example: a 47-year-old who used to love playing weekend basketball now dreads it because recovery takes days instead of hours

prednisone during induction): The Children's Cancer Group conducted a randomized trial that compared dexamethasone and prednisone in standard-risk B-ALL patients receiving a three-drug induction without an anthracycline.[6] Dexamethasone was associated with a superior event-free survival (EFS)