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Compounds such as apigenin, artemisinin, berberine, and curcumin, among others, have demonstrated significant immunomodulatory, anti-proliferative, pro-apoptotic, and anti-metastatic effects, both in vitro and in vivo

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Further analysis revealed morphological changes in the astrocytes of PTSD patients

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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly