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To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs

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However, they are also the major site of reactive oxygen species (ROS) production due to electron leakage during oxidative phosphorylation

doi: 10.1177/1073858407308518 158 BannaiS

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Bone is the most frequent site of breast cancer metastasis (102)