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Because the transsulfuration enzymes are involved in catabolism of Hcy/Met as well as in both producing and catabolizing Cys, the advantage of a pathway specifically for Cys catabolism that can be separately regulated is obvious in terms of control of tissue Cys concentrations

The spectrum of initial hypogonadism and later gonadal failure in thalassemia, results from the injury mediated by free radicals

Older mice were also found to have a defective response to Pseudomonas infection due to decreased upregulation of intercellular adhesion molecule 1, delaying infiltration of polymorphonuclear cells into the cornea and allowing for unchecked bacterial growth [36]

A follow-up study using Suncus murinus also revealed changes in GMA (without changes in signal structure) during acute and delayed phases and when tissue was taken at 90 min, the propagation of slow waves was affected in a regional-specific manner (e.g., duodenum and ileum versus stomach and colon), cisplatin also had tissue-specific acute (within minutes) effect on gastrointestinal tissue, in vitro (Tu et al., 2021)