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FDA approved : For the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

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The presence of TJs confers the BBB with high selectivity, effectively preventing the passage of most water-soluble substances and macromolecules through the paracellular pathway [28]

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10.1523/JNEUROSCI.16-03-01066.1996 3 AkahoshiN.YokoyamaA.NagataT.MiuraA.KamataS.IshiiI
