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PMID 21228876

doi: 10.1038/nature21029 153 WheelerMAClarkICLeeHGLiZLinnerbauerMRoneJMet al

The extended circulation time and sustained release profile further underscore the suitability of this platform for targeted CNS therapies (Jiang et al., 2025

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Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose
