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Both in vivo and in vitro studies have demonstrated that high glucose levels upregulate Apelin (APLN) in SC, which subsequently downregulates cell junctionrelated genes such as connexin 43 (Cx43) and zonula occludens-1 (ZO-1), ultimately compromising the integrity of the BTB (50)

Aschner, M., Rising, L

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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Kotelevtsev Y., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., Mullins J.J

6E) overlapped with the enhanced glycolytic score detected in these mice (Fig

These values vary by ethnic group