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These changes were accompanied by elevated nitric oxide production and aberrant expression of angiogenesis-related genes, including VEGFA, HIF-1, eNOS, iNOS, FGF-2, and ANG1

, 37 , 952-959, doi: Winkler, A., Njalsson, R., Carlsson, K., Elgadi, A., Rozell, B., Abraham, L., Ersal, N., Shi, Z

Since the completion of the Human Genome Project, sequencing methods have undergone dramatic improvements, transitioning from early Sanger sequencing to todays high-throughput next-generation sequencing (NGS) technologies

These are theoretical positives