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In certain embodiments the DNA interacting agent includes, but is not limited to calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), and the like

Long-term oncologic safety remains an open research question because the same migration-promoting and pro-angiogenic activity that supports wound closure has, in some murine melanoma models, correlated with increased metastasis

Its active ingredient is clinically proven to reduce skin discoloration, improving skin tone for a brighter and more even complexion

Dawes P, Cruickshanks KJ, Marsden A, Moore DR, Munro KJ

105, 1444714452.10.1073/pnas.0802696105 4 Al-GonaiahM.SmithR

PLoS One 8, e58275