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Blood-brain barrier tight junction permeability and ischemic stroke
This receptor is particularly important for weight loss as it is active in muscle, liver, kidney, and heart cells, increasing fatty acid oxidisation, like the action of HCA

doi: 10.1038/s41467-021-27766-8 62

Consistently, stress-induced depression models exhibit decreased prefrontal Bcl-2 protein levels and increased caspase-3/Bax expression, which can be reversed by the antidepressant venlafaxine [83]