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In the liver, the accumulation of lipids is thought to impair mitochondrial function, thus reducing fatty acid oxidation and increasing the production of reactive oxygen species (ROS) that trigger lipid peroxidation, DNA damage, and apoptosis

Genetic associations with CVD and its risk factors The data sources of all outcomes are shown in Additional file 1: Table S1

2005, 101: c174-179

Specifically, blood was drawn into a pre-cooled serum test tube wrapped in a cold gel bag, mixed, and allowed to clot in cold at least 60 minutes

This narrative review provides a comprehensive overview of the diverse modeling approaches, critically evaluating their strengths and limitations