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It represents an important gestational disorder and a precursor for lifetime disease, since up to half of women with a history of GDM will develop type 2 diabetes five to ten years after delivery [54]

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Recently, nonsteroidal antiinflammatory drugs have been shown to partially impair an equilibrium between biological functioning and degradation of aldosterone due to involvement of renal UGT2B7 in both the glucuronidation of aldosterone (deactivation) and the glucuronidation of NSAIDs (Knights et al., 2009)

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