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Several roles have been established for lncRNAs: regulation of chromatin structure by interacting with histones, repression or activation of gene expression through hybridization with genomic DNA, regulation of splicing, stabilization of messenger RNAs (mRNAs), and sponging of miRNAs (41)

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Multi-site or diffuse injuries: Patients with two or more active injury sites, or with a diffuse pattern of soft tissue damage that is not localized to a single structure