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PI3K/Akt and MAPK pathways have been shown to mediate downstream signaling of IGF-1 in these cells, although the relative importance of these pathways seems to differ depending on the model systems analyzed

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Rather than functioning as a short-lived, localized repair signal like MGF, IGF-1 LR3 exerts more systemic effects by promoting anabolic signaling across multiple tissues

The skin is the largest organ of the human body, which consists of three layers: epidermis, dermis, and subcutaneous

Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice

Indeed, the other bioavailable metabolites also caused significant neuroprotective effects under the same conditions (Supplementary Fig