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The microbial choline TMA lyase pathway could be considered a plausible molecular target for the treatment of atherosclerotic heart disease ( 3, 3-Dimethyl-1-butanol (DMB) is a structural analog of choline that appears to have certain mitigating properties on TMAO and other effects

Aust Fam Physician 2011

However, chemical inhibition of lactate production via LDH inhibitors diminishes Treg cell function in the TME by suppressing MOESIN Kla, ultimately enhancing the HCC response to anti-PD-1 treatment

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The present review examines the multifarious functions of TMAO and betaine with possible molecular mechanisms towards a better understanding of their emerging and diverging functions with probable implications in the prevention, diagnosis, and treatment of human diseases