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This drug inhibits the production of TNF- and INF- by dendritic cells and monocytes [31]

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Elevated serum cholesterol, liver damage, systemic inflammation, and hypoxic conditions can increase XO secretion via hepatic and other visceral pathways into the bloodstream and bind to the endothelial cell surface, initiating the overproduction of superoxide [77]

Early diagnosis and treatment play an important role in managing diseases and preventing health problems that lead to more severe consequences