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5.5 Engineered bacteria: metabolite-directed reprogramming of the tumor immune microenvironment Genetically engineered microorganisms represent a precision strategy to enhance cancer immunotherapy by delivering or modulating key microbial metabolites directly within the TME, thereby overcoming the limitations of systemic metabolite administration and inconsistent microbiome-driven metabolite production

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Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra
