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doi:10.1038/onc.2012.538

Zhou N, Leung CH, William WN Jr, Weissferdt A, Pataer A, Godoy MCB, Carter BW, Fossella FV, Tsao AS, Blumenschein GR, Le X, Zhang J, Skoulidis F, Kurie JM, Altan M, Lu C, Glisson BS, Byers LA, Elamin YY, Mehran RJ, Rice DC , Walsh GL, Hofstetter WL, Roth JA, Tran HT, Wu J, Solis Soto LM, Kadara H, Swisher SG, Vaporciyan AA, Gibbons DL, Lin HY, Lee JJ, Heymach JV, Negrao MV, Sepesi B, Cascone T

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The same phthalate metabolite can also activate PPAR, which, in addition to regulating adipocyte differentiation and metabolism of lipids and glucose [148,149], when overexpressed, has been associated with more aggressive features in TC, i.e., increased cell growth and tendency to generate metastasis, and appears to promote the transition from differentiated to TC undifferentiated histological types with a consequent worse prognosis [150]

1 Exactly why some people respond, and others dont, isnt fully understood