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That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported. However, there isnt much long-term research with high doses of NMN, according to Jillian

Lamantia V, Bissonnette S, Beaudry M, et al

doi: 10.1002/hep.23671
Oxidative damage in human gingival fibroblasts exposed to cigarette smoke

Vitamin B12 and redox homeostasis: cob (II) alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

They isolated the protein responsible, then synthesized the active 15-amino-acid fragment
