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That combination gastric origin, enzymatic stability, and remarkable tissue breadth is what has driven decades of continuous preclinical research interest in this unique compound

doi:10.1073/pnas.71.10.3879

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The authors suggested that the laryngeal effects observed in hamsters exposed to the vapour mixture were most probably caused by acetaldehyde alone (presumably based on comparison with results in studies on hamsters exposed to acetaldehyde alone)

It is worth noting that Amylyx Pharmaceuticals announced the results of the phase 3 PHOENIX trial of AMX0035 for the treatment of ALS in 2024