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The peptide maintained protective effects throughout natural lifespan without evidence of tolerance or diminishing efficacy

Funding Acquisition: M.J., M.A.C., P.V., B.H.C., P.S., N.B., R.J., S.O.R., E.F.F

Due to the global opioid crisis, the judicious use of chronic opioids is advised and only after informed decision-making with the patients and with periodic follow-ups to assess efficacy, adverse side effects, compliance, and potential of abuse or misuse

Compound: BPC-157 (Hydrochloride form)

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In the second part of the review, the current evidence of the role of impaired barrier function in the pathophysiology of selected gastrointestinal and liver diseases is discussed