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Regulation of cGAS activity and downstream signaling

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This is further supported in mouse models of acute and chronic inflammation wherein KEAP1 suppression of NRF2 is critical for expansion of CD8 + T cells, metabolic reprogramming, and generation of stem-like T cells which enhance long term immunity [67]

Notably, vitamin B6-conjugated compounds are internalized through putative VTC-dependent pathways in cancer cells that exhibit increased dependency on vitamin B6

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