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However, glutamine is considered as a conditionally essential amino acid when de novo synthesis of glutamine cannot meet the energy demand for the rapid proliferation of cancer cells

increased expression of NEAT1 downregulates let-7a, removing the miRNA block on IGF-2 expression, and resulting in increased NSCLC cell proliferation, migration and invasion [25]

Philippot G, Forsberg E, Tahan C, Viberg H, Fredrikson R

2022;119:e2117396119

Sirpiglenastat (Drp-104) induces antitumor efficacy through direct, broad antagonism of glutamine metabolism and stimulation of the innate and adaptive immune systems

Scientific opinion on dietary reference values for niacin
