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Some enzymes genetically break it down better than others (one of the reasons some handle alcohol than others.) This alcohol breakdown in the liver creates molecules that can lead to the production of reactive oxygen species (ROS) free radicals - tiny, very active molecules that contain oxygen

Meftah et al., 2020)

Restored antioxidant circulating capacities in AIDS west African patients receiving an antioxidant nutraceutical Cucumis melo extract rich in Superoxide dismutase activity, H Chenal, M

The Latin term, substantia nigra, means black substance

Without adequate glutathione, the free radicals begin damaging cellular membranes, mitochondrial DNA, and endothelial linings