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After that, divalent metal transporter 1 (DMT1) transports Fe2 + into the labile iron pool in the cytoplasm (Katsarou and Pantopoulos, 2020)

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Prior to eventual internalization by distant immune cells, the formation of MVs, which also contain important immune-cell receptors and inhibitory complement receptors, may contribute to an immune or tolerogenic microenvironment for MM cells in the bone marrow (BM) niche [25] [26]

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