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10.1021/mp7001363 223

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Uncleared extracellular DNA (for example, microsomal-bound DNA) can be recognized as a danger signal activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and promoting type I interferon secretion to drive lupus-like autoimmunity (17-19)

In organisms undergoing catabolism, the E3 ligases Atrogin-1 (also called MAFbx or FBXO32) and MuRF-1 (also called Trim63) are specifically expressed

Chronic oral methylphenidate administration to periadolescent rats yields prolonged impairment of memory for objects

However, alcohol can lower blood pressure