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The secretory pathway, including the endoplasmic reticulum, the Golgi and the endosomal system play central roles in this trafficking (Figure 1)

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Therefore, the modulation and prevention of these situations during muscle damage and stress could be regulated by taking oral anti-inflammatory or antioxidant supplements [20]

However, its overactivation leads to depletion of NAD + and ATP, consequently disturbance in energy production and mitochondrial function, which have been reported in ME/CFS as other pathologic conditions [133]

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