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Mechanistically, the mutated KRAS oncoprotein hypermethylates and silences the expression of multidrug and toxic compound extrusion 1 (MATE1), a specific pump that expels metformin from the tumor cells by upregulating DNA methyltransferase 1 (DNMT1)

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It has been shown that dysregulation of the proBDNF/BDNF axis is intricate in the emergence of several neuropsychiatric conditions, including depression (Pettorruso et al., 2024)

Injectable glutathione typically functions as an acute antioxidant support, while tirzepatide provides sustained metabolic signaling

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This is important to note, as secondary dystonia can potentially be treatable depending on the underlying cause, particularly in metabolic disorders (114)