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After this we discuss the functional organization of the enteric nervous system and its relation to the autonomic nervous system

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More generally, potentially pathological changes to the NO nitrergic co-transmission system have been reported to correlate with a range of additional psychiatric conditions, including other anxiety disorders, depression, and bipolar disorder (Dhir and Kulkarni, 2011

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Without offering a citation for a published paper or sharing any data, Sikirics 2025 review states that this clinical trial found that the drug was safe and well-tolerated in humans