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However, inhibition of GLS activity can reduce ATP and GSH levels produced by cardiomyocytes under oxidative stress conditions

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For example, low-dose bortezomib induces autophagy and reduces mutant huntingtin aggregation in HD models

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The expanded Enterobacteriaceae release LPS, activating the TLR4/MyD88 axis to upregulate epithelial NOX1 expression, thereby driving secondary ROS bursts that amplify epithelial barrier disruption and inflammatory cascades [404]