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Common Side Effects XII

Although we did not directly solicit feedback to our update, we did receive some public comments, which we summarize as follows

Interestingly, ABHD5 mutations causative in CDS do not co-localize to LDs and are unable to stimulate PNPLA2 lipolytic activity (30), demonstrating an important function for the interaction in the etiology of CDS and lipid storage

Blocking NNMT activity has been shown in research settings to influence body composition, leading to reduced adipocyte size, alterations in fat mass, and measurable changes in plasma biomarkers such as glucose and cholesterol

Weight loss injections are typically recommended for adults with: A BMI of 30+ Or a BMI of 27+ with a related health condition like diabetes, PCOS, or high blood pressure Your doctor may also suggest injections if you've tried other methods without success and need additional support

A GP or specialist can assess underlying health conditions that may increase the risk of adverse effects and can advise on licensed, evidence-based alternatives available through NHS or private prescribing pathways