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More precisely, the complex bearing the most lipophilic benzoate ligand, 3P , showed the highest in vitro antiproliferative activity (mean IC 50 equal to 2.6 M), whereas the complexes with a more hydrophilic carboxylate, such as succinate and acetate, 4P and 5P , were endowed with a lower cytotoxic activity (mean IC 50 of 30.4 and 11.1 M, respectively)

p21 exerts this anti-apoptotic function through several key mechanisms, predominantly when localized in the cytoplasm

Wasser MN, Geelkerken RH, Kouwenhoven M, van Bockel JH, Hermans J, Schultze Kool LJ

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958 Cit-AuNRs@Anti-TRPV1 show flexible photothermal response and good biocompatibility under NIR irradiation