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T-tubule remodeling in cardiomyocytes TMAO disturbed myocardial excitation-contraction coupling by inducing Ca 2+ dysfunction (103)

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Carnitine Synthesis and Dietary Uptake In animal tissues, L-carnitine concentrations are relatively high, typically between 0.2 and 6 mmol/kg with almost all in the heart and skeletal muscle, and it is synthesised de novo in animal cells by a multi-step process with N -trimethyl-lysine derived from protein degradation as the primary precursor and butyrobetaine as an intermediate