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Oncometabolite d-2-hydroxyglutarate impairs -ketoglutarate dehydrogenase and contractile function in rodent heart

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The ketogenic diet has been found to regulate key signaling pathways that both enhance mitochondrial function and promote neuroprotection (226) and is recommended for a wide variety of mitochondrial disorders (227, 228)

Stimulation of carnitine palmitoyltransferase 1 improves renal function and attenuates tissue damage after ischemia/reperfusion

Seven of the eight dogs survived