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Description
However, many promising drug candidates fail to achieve sufficient systemic exposure because of solubility and permeability limitations, metabolic instability, or formulation-related issues

[PubMed: 11756331] 19

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K., Mikhailovich V

Multiple mechanisms are involved in the switching of the endothelium into a hypercoagulative state, such as TF coagulation activation, platelet pro-aggregation due to increased release of VWF, NET-mediated thrombin generation and fibrinolytic shutdown
