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In rats fed a high-fat diet, an increase in visceral fat accumulation and insulinemia were associated with enhanced catalase activity in liver [47], while amelioration of these features by pioglitazone decreased catalase activity [47]

Researchers have identified other mitochondrial-derived peptides, such as Humanin and SHLPs, or small humanin-like peptides, but MOTS-C exhibits unique effects on energy sensing and gene regulation in response to metabolic stress

Borg scale) were monitored every 10 min during exercise

doi: 10.1016/j.freeradbiomed.2018.10.423

ET is a rare antioxidantcytoprotectant capable of crossing the bloodbrain barrier, a feature that is necessary to treat neurodegenerative disorders where oxidative stress plays a central role in disease progression (111)

Moreover, ROS serves as signaling molecules that enhance cellular proliferation and survival pathways