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Hiremath et al., 1998

Studies have shown that mitochondrial uncoupling protein 2 (Ucp2) is upregulated in phagocytes that internalize ACs [77]

These effects depend on integrin 1 and 1 pathway activation, creating functional outcomes of: Enhanced endothelial cell proliferation Increased cell migration to injury sites Improved tubule formation for angiogenesis No cytotoxic effects across wide concentration ranges Hair Follicle Stem Cells Hair follicle stem cells undergo amplification, demonstrated by follicle enlargement in mice

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Metabolic byproducts such as 2-deoxy-D-ribose also trigger ferroptosis by degrading the core subunit of System Xc (xCT) and consuming GSH (Kim et al., 2023)