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Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice

Unsupervised clustering of the top 500 ANOVA-variable proteins identified two major expression clusters, with the most pronounced alterations occurring in the double knockout (Fig

Consequently, considering iron chelators to impede ferroptosis may present a promising therapeutic approach for associated diseases [8, 69,70,71,72,73]

Tools such as CRISPR screens, chromatin conformation mapping, single-cell transcriptomics and epigenetic profiling are now enabling the dissection of regulatory networks driving beta cell dysfunction

However, there still exist major gaps in understanding how HSCs respond to stress, which hinders the development of strategies to maintain or expand functional HSCs in vivo

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