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The cerebellum, despite its extensive connections with the rest of the brain, has received considerably less attention

The oral formulation almost certainly delivers less bioavailable peptide than equivalent injectable doses, but the delivered amount may still cross therapeutic thresholds for some individuals and conditions

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While management of BP in family practice has increased in the past 20 years, a large proportion (23%) remain uncontrolled with persisting SBP 140 mmHg or DBP 90 mmHg independent of the treatment.7,1214 Current guidelines for treatment of hypertension recommend starting monotherapy with any of the standard BP medication classes, including angiotensin-converting enzyme inhibitors, angiotensin II-receptor blockers, calcium-channel blockers, or diuretics in patients with uncomplicated hypertension.15,16 While guidelines are clear about when to consider treatment with BP medication, they are less clear about which BP medication class to start treatment with in patients with uncomplicated hypertension and no comorbidities