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he intimating that he was too cowardly to show himself in open and honorable conflict, M'Kean challenged him to meet him in single combat, or with an equal number of men, to try their skill, courage, and strength

This accumulation may affect neuronal function and viability, potentially exacerbating neuroinflammation and compromising BBB integrity (Joshi et al., 2019)

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H.SawamuraT.et al (2006)

eLife 10 , e63532 (2021)

Mortality/Morbidity: Oral melanoma often is overlooked or clinically misinterpreted as a benign pigmented process until it is well advanced