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Phosphorylated IRF3 then translocates to the nucleus, thereby promoting the transcription of IFN-

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In a mouse model of LPS-induced ALI, both DC-specific PFKFB2 knockout and DC-targeted delivery of HIF-1 inhibitor-loaded nanoparticles effectively suppressed DC maturation and alleviated ALI severity [105]

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(available at: [DOI] [PMC free article] [PubMed] [Google Scholar] Iommiello VM, Albani E, Di Rosa A, Marras A, Menduni F, Morreale G, Levi SL, Pisano B, Levi-Setti PE.2015

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