glutathione s-transferase gsts catalyze the conjugation role of S-transferases in human disease pathogenesis and their current inhibitors Phase II - Glutathione Conjugation

[DOI] [PubMed] [Google Scholar] 119.Larini A, Bianchi L, Bocci V

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SESTRIN2 downregulation inhibits the interaction between BECLIN1 and PARKIN, preventing optimal mitochondrial accumulation of PARKIN

641 Moreover, 9( S )-HODE, but not 13( S )-HODE (the equivalent ( R )-enantiomers were not evaluated), inhibited the proliferation of normal human epidermal keratinocytes cells by suppressing DNA synthesis, while inducing the secretion of inflammatory cytokines IL-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF)

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Nevertheless, evidence was obtained that the enzymatic reaction is also required to sustain ascorbate accumulation induced in these conditions (Hamada et al