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In cerebral I/R injury, increases in thrombin in neurons activate cPLA2 and promote the release of arachidonic acid, which is esterified by ACSL4 and utilized as a ferroptotic fuel

Discovery of an AKT degrader with prolonged inhibition of downstream signaling

Furthermore, glutathione in its reduced form (GSH) acts as a hydrogen donor in the detoxification process of hydrogen peroxide

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The first, mediated by NOX2, may negatively regulate T cell-dependent antibody production

Results of a previous study have revealed that miR-148a-3p acts as a tumor suppressor in CRC through targeting SLC7A11 and activating ferroptosis (85)