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In cell culture models of human macrophage foam cells, the inability to clear cholesterol from macrophages with compromised lysosome function continues even in the presence of compounds that stimulate efflux (161,163)

As the ER lacks glutathione reductase activity, GSSG must be exported to the cytosol by SLC33A1 to maintain redox homeostasis

The rml1 ( rootmeristemless1 ) mutant has less than 5% of wild-type glutathione contents

For example, sulfur functionalization in the second shell alter the electronic structure of the FeN 4 site, increasing the electron density at the Fermi level and enhancing electron transfer from the active site to the key intermediate HO 2 , thereby boosting oxidase-like activity 126

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