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Although 25 selenoproteins are tissue-specific finetuned in Se deficiency (85) and deiodinase is a highly conserved selenoprotein, the content activity of deiodinase also decreases in severe Se deficiency, when the body synthesizes significantly less T3 and the inhibitory effect on TSH is diminished

Aging also contributes to synaptic dysfunction, impaired protein homeostasis, calcium dysregulation, and increased permeability of the blood-brain barrier [47]

10.1016/j.ijcard.2016.04.168 8 DeshmukhA.GhannamM.LiangJ.SaeedM.CunnaneR.GhanbariH.et al (2021)

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Askling J, Linet M, Gridley G, Halstensen TS, Ekstrom K, Ekbom A
2020;21(21) doi: 10.3390/ijms21217890.7890 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Tamai I
