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Outcome of trimodality-eligible esophagogastric cancer (EC) patients who declined surgery after preoperative chemoradiation

A double-blind, placebo-controlled trial could be helpful in exploring these questions (of note, the authors of this paper are currently conducting a clinical trial with secondary and exploratory outcomes aimed to explore symptomatic benefits, NCT04584346)

10.1136/bmjdrc-2019-001081 187 ZhangP.DongG.SunB.ZhangL.ChenX.MaN.et al (2011)

Pregnant women may require additional folate supplementation (as advised by health professionals) to prevent congenital neural tube defects such as spina bifida (Fig 3)

The berberine-mediated inhibition of NF- B signaling is partially due to the suppression of inhibitory factor B (I- B) kinase, which stabilizes I- B, thereby inhibiting nuclear translocation of the NF- B p65 subunit [53]

Thus, iNOS can be considered a potential therapeutic target in breast cancer [302], since iNOS expression is positively correlated with tumor grade, stage and metastasis [303,304]